MULTIPLEX PCR PANEL | CNS PATHOGEN DETECTION

Genplex™ Meningitis / Encephalitis Panel

A comprehensive multiplex PCR panel for rapid detection of bacterial, viral, fungal, and antimicrobial resistance (AMR) gene targets directly from cerebrospinal fluid (CSF). Enables timely identification of CNS pathogens in meningitis and encephalitis — critical for early targeted therapy and improved patient outcomes.

Sample: CSF (Cerebrospinal Fluid) CNS Pathogen Detection Bacterial, Viral, Fungal & AMR Rapid Results vs. Culture
Order Information Key Features
Genplex™ Meningitis / Encephalitis Panel

Rapid CNS Pathogen Identification — Meningitis & Encephalitis

Meningitis and encephalitis are life-threatening infections of the central nervous system (CNS) requiring immediate diagnostic workup and empiric antimicrobial treatment. Identifying the causative pathogen rapidly is critical to guide de-escalation from empiric broad-spectrum therapy.

Traditional CSF culture and serology methods are slow and have limited sensitivity. The Genplex™ Meningitis/Encephalitis Panel uses multiplex PCR technology to simultaneously detect bacterial, viral, and fungal pathogens along with AMR resistance genes directly from CSF — in a fraction of the time.

The panel covers 8 bacterial targets (including MTB, NTM), 7 viral targets (CMV, HSV-1, HSV-2, Enterovirus, VZV, etc.), 1 fungal target (Cryptococcus), and AMR resistance genes — giving clinicians a comprehensive CNS infection profile.

Key Specifications

  • Sample: Cerebrospinal Fluid (CSF)
  • 8 Bacterial targets including MTB & NTM
  • 7 Viral targets (CMV, HSV-1, HSV-2, Enterovirus, VZV, Parvovirus B19, Parechovirus)
  • 1 Fungal target: Cryptococcus neoformans/gattii
  • AMR resistance genes included
  • Qualitative multiplex PCR detection

Key Highlights

Advanced molecular diagnostic capabilities engineered for clinical excellence and research-grade precision.

Rapid Turnaround

Delivers CNS pathogen identification in hours — enabling faster targeted therapy decisions vs. traditional culture.

High Sensitivity

Superior sensitivity in detecting pathogens directly from CSF, even at low pathogen loads.

Comprehensive CNS Coverage

Simultaneously detects bacterial, viral, fungal pathogens, and AMR genes from a single CSF specimen.

AMR Gene Detection

Identifies key resistance genes to guide empiric antibiotic de-escalation and targeted therapy.

CNS-Optimized Panel Design

Targets selected based on clinical prevalence and relevance in bacterial and viral CNS infections.

Direct CSF Testing

No culture required — results directly from CSF without pre-enrichment or prolonged incubation.

Detection Panel

Comprehensive multiplex detection covering a broad spectrum of clinically relevant pathogens and resistance markers.

Bacterial Pathogens (8)
  • Escherichia coli K1
  • Haemophilus influenzae
  • Listeria monocytogenes
  • Neisseria meningitidis
  • Streptococcus agalactiae
  • Streptococcus pneumoniae
  • Non-Tuberculous Mycobacteria (NTM)
  • Mycobacterium tuberculosis (MTB)
Viral Pathogens (7)
  • Cytomegalovirus (CMV)
  • Enterovirus
  • Herpes Simplex Virus 1 (HSV-1)
  • Herpes Simplex Virus 2 (HSV-2)
  • Human Parvovirus B19
  • Human Parechovirus
  • Varicella Zoster Virus (VZV)
Fungal Pathogens (1)
  • Cryptococcus neoformans/gattii
AMR Resistance Genes
  • blaVIM (IMP)
  • blaPCE (KPC)
  • blaOXA-48-like
  • blaVIM (NDM)
  • blaVIM (VIM)
  • mecI-1
  • HSBL
  • NdeTLa-M
  • mecA
  • mcrC
  • mcr5
  • vanB

Clinical Applications

Designed for diverse diagnostic and research use cases across the clinical spectrum.

Bacterial Meningitis

Rapid identification of bacterial CNS pathogens for early targeted antibiotic therapy.

Viral Encephalitis

Detection of neurotropic viruses including HSV-1/2, CMV, Enterovirus, and VZV from CSF.

Cryptococcal Meningitis

Detection of Cryptococcus neoformans/gattii in immunocompromised patients.

Antimicrobial Stewardship

AMR gene detection enables rapid de-escalation from broad-spectrum empiric therapy.

Technical Specifications

Parameter Value / Description
Sample Type Cerebrospinal Fluid (CSF)
Bacterial Targets 8 (including MTB & NTM)
Viral Targets 7 (CMV, HSV-1, HSV-2, Enterovirus, VZV, Parvovirus B19, Parechovirus)
Fungal Targets 1 (Cryptococcus neoformans/gattii)
AMR Genes Included
Detection Method Qualitative Multiplex PCR
Intended Use In Vitro Diagnostic (IVD)
Storage -20°C

Ordering Information

For in vitro diagnostic use. Contact your regional distributor or ProbGen representative to place an order.

Product Name Cat. No. Pack Size
Genplex™ Meningitis / Encephalitis Panel GP1058 48 tests
Genplex™ Meningitis / Encephalitis Panel GP1059 96 tests

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